رَبِّ لَا تَذَرْنِي فَرْدًا وَأَنْتَ خَيْرُ الْوَارِثِينَ
Rabbi la tadharni fardan wa Anta khayrul-warithin
My Lord, do not leave me alone with no offspring, while You are the best of inheritors.
This is the du'a of Prophet Zakariyya (AS) when he yearned for a child in his old age. Despite both he and his wife being beyond the typical age, Allah answered his du'a and granted him Yahya (AS). It is especially meaningful for couples struggling with infertility.
Related Du'as
رَبِّ هَبْ لِي مِن لَّدُنكَ ذُرِّيَّةً طَيِّبَةً ۖ إِنَّكَ سَمِيعُ الدُّعَاءِ
My Lord, grant me from Yourself good offspring. Indeed, You are the Hearer of supplication.
Sahihرَبَّنَا هَبْ لَنَا مِنْ أَزْوَاجِنَا وَذُرِّيَّاتِنَا قُرَّةَ أَعْيُنٍ وَاجْعَلْنَا لِلْمُتَّقِينَ إِمَامًا
Our Lord, grant us from among our spouses and offspring comfort to our eyes, and make us a leader for the righteous.
Sahihرَبِّ اجْعَلْنِي مُقِيمَ الصَّلَاةِ وَمِن ذُرِّيَّتِي رَبَّنَا وَتَقَبَّلْ دُعَاءِ رَبَّنَا اغْفِرْ لِي وَلِوَالِدَيَّ وَلِلْمُؤْمِنِينَ يَوْمَ يَقُومُ الْحِسَابُ
My Lord, make me an establisher of prayer, and from my descendants. Our Lord, accept my supplication. Our Lord, forgive me and my parents and the believers on the Day the account is established.
Sahihرَبِّ هَبْ لِي مِن لَّدُنكَ وَلِيًّا يَرِثُنِي وَيَرِثُ مِنْ آلِ يَعْقُوبَ وَاجْعَلْهُ رَبِّ رَضِيًّا
My Lord, grant me from Yourself an heir who will inherit from me and from the family of Ya'qub. And make him, my Lord, pleasing to You.
Sahih